Biomarkers
Cancers often arise as a result of genomic instability and the evolution of neoplastic cell populations with variable types of genetic alterations.
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Low-grade glioma (LGG) represents the most frequently occurring central nervous system tumor among children, accounting for nearly one-third of all pediatric brain tumors.
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Oncogenic gene fusions are hybrid genes caused by DNA rearrangements, leading to the generation of protein products that can perturb key components of cellular activity, thus resulting in deregulated growth, proliferation, and differentiation.
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