In this final WCMC clinical commentary entitled, The Impact of Hedgehog Pathway Inhibitors on the Management of Patients with Basal Cell Carcinoma, Joel Claveau, MD, CSPQ, FRCPC; Dirk Schadendorf, MD; Nicole Basset-Seguin, MD, PhD and Aleksandar Sekulic, MD, PhD discuss how Hedgehog Pathway Inhibitors opened a new chapter of treatment and how it will have a significant impact for patients with basal cell carcinoma.