December 2015, Vol. 4, No. 6

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Sample Size Calculation for Single-Arm Phase 2 Prostate Cancer Trials

Prostate Cancer

Prostate cancer remains one of the major health issues for men worldwide and is the second leading cause of cancer-related death in males in the United States…

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2015 Breast Cancer Symposium - December 28, 2015

The Affordable Care Act: Extending Coverage to Millions of Americans

A closer look at the $2.7 trillion spent on healthcare in the United States in 2011 reveals a system of extreme imbalances, characterized by excessive consumption of care on the one hand and lack of access to necessary care on the other. The Affordable Care Act (ACA), outlined by Otis [ Read More ]

Genetic Counseling - December 28, 2015

Inherited Colorectal Cancer: POLE and POLD1

The association of POLE and POLD1 with colorectal cancer risk was demonstrated in 2013. Palles and colleagues studied families with a dominant pattern of inherited colorectal cancer and multiple adenomas through whole genome sequencing.1 Through these efforts, they identified germline mutations in POLE and POLD1 as high-penetrance genes predisposing to [ Read More ]