December 2015, Vol. 4, No. 6

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Sample Size Calculation for Single-Arm Phase 2 Prostate Cancer Trials

Prostate Cancer

Prostate cancer remains one of the major health issues for men worldwide and is the second leading cause of cancer-related death in males in the United States…

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FDA Approvals, News & Updates - December 28, 2015

FDA Approves Portrazza to Treat Advanced Squamous Non–Small Cell Lung Cancer

On November 24, 2015, the FDA approved Portrazza (necitumumab) in combination with 2 forms of chemotherapy to treat patients with advanced (metastatic) squamous non–small cell lung cancer (NSCLC) who have not previously received medication specifically for treating their advanced lung cancer. Lung cancer is the leading cause of cancer death [ Read More ]

Genetic Counseling - December 28, 2015

Inherited Colorectal Cancer: POLE and POLD1

The association of POLE and POLD1 with colorectal cancer risk was demonstrated in 2013. Palles and colleagues studied families with a dominant pattern of inherited colorectal cancer and multiple adenomas through whole genome sequencing.1 Through these efforts, they identified germline mutations in POLE and POLD1 as high-penetrance genes predisposing to [ Read More ]