August 2016, Vol. 5, No. 6

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Presenting Emerging Data and Calling for Molecular Tumor Board Case Studies

Al B. Benson III, MD, FACP, FASCO

Letter to Our Readers

Untitled-17Dear Colleague,

On behalf of all of us at Personalized Medicine in Oncology (PMO), I hope you are enjoying the summer and finding time for the recreation necessary to return to the care of your patients with a renewed spirit. After the busy ASCO season, we have taken advantage of this time to review data from this important meeting and are pleased to offer the most critical information in this issue. You’ll find a host of the best reports from ASCO all related to personalized medicine, from the latest in immunotherapies and matching therapy to molecular alterations. We hope this compilation is of value to you and your practice.

Also in this issue, we are delighted to feature an article by PMO Editorial Board member Darren Sigal, MD, and his colleague David Hermel, MD. The authors take a critical look at emerging data regarding anti–PD-1 agents as bio­markers.

Many oncology centers host molecular tumor boards during which multidisciplinary participants discuss patients with all types of cancer whose tumors have been analyzed with advanced genomic diagnostic tests. If you participate in such a board, we want to hear from you with your case study submissions for our Molecular Tumor Board department. Submissions should include case presentation, actionable biomarker identification, therapeutic course, and outcomes. Author guidelines can be found at www.personalizedmedonc.com/author-guidelines.

Enjoy what remains of summer, and we hope you will consider submitting a case study. Thank you for your loyal readership.

Sincerely,

Al B. Benson III, MD, FACP, FASCO
Coeditor in Chief
Personalized Medicine in Oncology

Immunotherapy - August 5, 2016

“Check”-ing the Data: A Review of Immune Checkpoint Inhibitor Biomarkers

David Hermel, MD
Resident Physician, Internal Medicine
University of Southern California, Los Angeles, CA

Darren Sigal, MD
Attending Physician, Division of Hematology/Oncology
Scripps Clinic Medical Group, San Diego, CA

William Coley’s late 19th-century observation of “spontaneous tumor regression” following injection of streptococcal organisms into the bloodstream of his patients set the stage for more than a century of public debate over the relationship between cancer and the immune system.1 Only recently, with the success of immune checkpoint inhibitors in [ Read More ]

ASCO - August 5, 2016

“Smart Bomb” Drug: Rova-T Promising in SCLC

The antibody-drug conjugate rovalpituzumab tesirine (Rova-T) may be a new option for treatment of small cell lung cancer (SCLC), a disease with a very poor prognosis and few treatment options. Rova-T looked particularly promising in SCLC tumors that overexpress delta-like protein 3 (DLL3), according to a first-in-human trial presented at [ Read More ]