August 2016, Vol. 5, No. 6

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Presenting Emerging Data and Calling for Molecular Tumor Board Case Studies


Letter to Our Readers

Untitled-17Dear Colleague,

On behalf of all of us at Personalized Medicine in Oncology (PMO), I hope you are enjoying the summer and finding time for the recreation necessary to return to the care of your patients with a renewed spirit. After the busy ASCO season, we have taken advantage of this time to review data from this important meeting and are pleased to offer the most critical information in this issue. You’ll find a host of the best reports from ASCO all related to personalized medicine, from the latest in immunotherapies and matching therapy to molecular alterations. We hope this compilation is of value to you and your practice.

Also in this issue, we are delighted to feature an article by PMO Editorial Board member Darren Sigal, MD, and his colleague David Hermel, MD. The authors take a critical look at emerging data regarding anti–PD-1 agents as bio­markers.

Many oncology centers host molecular tumor boards during which multidisciplinary participants discuss patients with all types of cancer whose tumors have been analyzed with advanced genomic diagnostic tests. If you participate in such a board, we want to hear from you with your case study submissions for our Molecular Tumor Board department. Submissions should include case presentation, actionable biomarker identification, therapeutic course, and outcomes. Author guidelines can be found at

Enjoy what remains of summer, and we hope you will consider submitting a case study. Thank you for your loyal readership.


Coeditor in Chief
Personalized Medicine in Oncology

ASCO - August 5, 2016

Liquid Biopsies Have High Correlation with Tissue Biopsy for Genetic Mutations

Somatic alterations in circulating tumor (ct) DNA, ie, a liquid biopsy, are consistent with alterations found in tissue biopsy, with the exception of resistance mutations, in patients with advanced solid tumors, said Philip Mack, PhD. The finding, which comes from a genomic analysis of blood samples from more than 15,000 [ Read More ]

ASCO - August 5, 2016

Combination Immunotherapy Makes Progress in Advanced Melanoma

Evidence is mounting that 2 immunotherapies are better than 1 as first-line treatment of advanced melanoma. A phase 3 study showed that nivolumab plus ipilimumab was superior to either agent alone, and a phase 1 study suggests that pembrolizumab can be safely and effectively combined as first-line treatment in this [ Read More ]