The Lynx Group

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CAR-T Cells Moving Along in Hematologic Malignancies

There is excitement about immunotherapy for the treatment of several types of tumors, and the list of cancers amenable to this approach is expanding. In addition to the programmed death-1 (PD-1) and its ligand 1 (PD-L1) immunotherapies, chimeric antigen receptor T (CAR-T)-cell therapy is also garnering much interest, especially in [ Read More ]

Pembrolizumab in Advanced Urothelial Bladder Cancer

Advanced urothelial bladder cancer (UBC) joins the list of tumor types for which treatment with pembrolizumab, a programmed death-1 (PD-1) inhibitor with dual blockade of its ligands PD-L1 and PD-L2, holds promise. Updated safety and efficacy data from the phase 1b KEYNOTE 012 study showed an overall response rate (ORR) [ Read More ]

Pembrolizumab Has Encouraging Preliminary Activity in Advanced PD-L1–Positive Gastric Cancer

An analysis of the KEYNOTE-012 phase 1 trial suggests that pembrolizumab has durable efficacy in heavily pretreated patients with programmed death-1 (PD-1) ligand 1 (PD-L1)-positive gastric cancer. Pembrolizumab had a manageable safety profile with no new or unexpected events observed (Abstract 4001). “PD-L1 expression on both tumor and immune cells [ Read More ]

Older Adults with ALL and CAR-T Therapy

Although acute lymphoblastic leukemia (ALL) is predominantly a disease found in children, the incidence peaks again in older adults, who have a high risk of treatment-related mortality. Thus, effective and better tolerated treatment of ALL in older patients is an unmet clinical need, said David I. Marks, MD, PhD, University [ Read More ]

Anti–PD-L1 Alone or Combined with Chemotherapy for NSCLC

Preliminary clinical trials suggest that the investigational programmed death-1 ligand 1 (PD-L1) inhibitor atezolizumab has excellent single-agent activity and also can be safely combined with platinum-based chemotherapy for the treatment of non–small cell lung cancer (NSCLC). Atezolizumab is 1 of 3 anti–PD-L1 agents in development; none is currently approved by [ Read More ]

The Fourth Annual World Cutaneous Malignancies Congress

The Fourth Annual World Cutaneous Malignancies Congress (WCMC) took place in Seattle, WA, on July 24-25, 2015. The WCMC is a 2-day congress dedicated to informing, educating, and fostering the exchange of clinically relevant information in the field of cutaneous malignancies on topics in melanoma, basal cell carcinoma, squamous cell [ Read More ]

New CLL-IPI Scoring System Validated as Clinically Applicable

Traditional staging systems for chronic lymphocytic leukemia (CLL), such as Rai and Binet, need to be updated in the current era of more effective therapies. A group of investigators has developed a CLL-IPI (International Prognostic Index) scoring system that combines genetic risk factors with clinical stage, age, and ?2-microglobulin into [ Read More ]

IDH1 Gene and ATRX Gene Prognostic in Anaplastic Astrocytoma

The IDH1 gene and the ATRX gene appear to be potential prognostic markers for anaplastic astrocytoma, a rare form of brain cancer, according to findings of a phase 3 trial. Patients with a mutated IDH1 gene survived for a mean of 7.9 years after diagnosis versus 2.8 years for patients [ Read More ]

Combination Targeted and Immunotherapy Feasible in Advanced Melanoma

One of the burning questions about the new agents available to treat melanoma is how best to combine and/or sequence them. A phase 1 study showed the feasibility of combining a BRAF inhibitor and a MEK inhibitor plus a programmed death-1 ligand 1 (PD-L1) inhibitor (MEDI4736). These 3 agents can [ Read More ]

GADOLIN Trial: Obinutuzumab Moves into Indolent Lymphoma

Results from the phase 3 GADOLIN trial provide the first proof of efficacy for obinutuzumab in indolent non-Hodgkin lymphoma (NHL). Obinutuzumab added to standard bendamustine chemotherapy more than doubled progression-free survival (PFS) in patients with rituximab-refractory indolent lymphoma: median PFS was 29.2 months with obinutuzumab/bendamustine versus 14 months with bendamustine [ Read More ]

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