The Lynx Group

Society of Gynecologic Oncology

Mutation Testing Encouraged for All Ovarian Cancer Patients

All women with ovarian cancer should have the option of genetic testing, regardless of tumor histology, investigators in a retrospective, tissue-based analysis of a randomized trial concluded. Tumors with defects in homologous recombination (HR)-BRCA1/2 or otherwise-had as much as a 9-month advantage in progression-free survival (PFS) and as much as [ Read More ]

Genomic Instability Score Predicts Survival in Ovarian Cancer

A higher score on a composite index of homologous recombination deficiency (HRD) correlated with improved progression-free survival (PFS) and overall survival (OS) in ovarian cancer treated with platinum-containing chemotherapy, results of a tissue-based validation study showed. An HRD score that met or exceeded the predefined threshold reduced the hazard ratio [ Read More ]

Immunotherapy May Prolong Recurrence-Free Survival in Advanced Ovarian Cancer

Personalized medicine in the form of immunother­apy holds promise for maintenance treatment of late-stage ovarian cancer, according to a phase 2 study. The personalized vaccine, made from the patient’s own tumor cells, was able to prolong recurrence-free survival compared with standard of care, according to study results presented at the [ Read More ]

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