All women with ovarian cancer should have the option of genetic testing, regardless of tumor histology, investigators in a retrospective, tissue-based analysis of a randomized trial concluded. Tumors with defects in homologous recombination (HR)-BRCA1/2 or otherwise-had as much as a 9-month advantage in progression-free survival (PFS) and as much as [ Read More ]
A higher score on a composite index of homologous recombination deficiency (HRD) correlated with improved progression-free survival (PFS) and overall survival (OS) in ovarian cancer treated with platinum-containing chemotherapy, results of a tissue-based validation study showed. An HRD score that met or exceeded the predefined threshold reduced the hazard ratio [ Read More ]
Personalized medicine in the form of immunotherÂapy holds promise for maintenance treatment of late-stage ovarian cancer, according to a phase 2 study. The personalized vaccine, made from the patient’s own tumor cells, was able to prolong recurrence-free survival compared with standard of care, according to study results presented at the [ Read More ]
