The Lynx Group

Prostate Cancer

Personalized Approach to Prostate Cancer

In 2016, prostate cancer is projected to be the most common cancer among men (excluding skin cancers), occurring in 180,890 and causing death in 26,120.1 The median age at time of diagnosis of prostate cancer is 66 years, with the median age at death being 80 years.2 Simply considering both [ Read More ]

Sample Size Calculation for Single-Arm Phase 2 Prostate Cancer Trials

Prostate cancer remains one of the major health issues for men worldwide and is the second leading cause of cancer-related death in males in the United States…

A Genetic-Based Approach to Individualized Prostate Cancer Screening and Treatment

Since its introduction as an aid to the early detection of prostate cancer (PC) in the 1990s, routine prostate-specific antigen (PSA) testing has been associated with a stage migration toward increased diagnoses of organ-confined, low-grade PC.1-4 The result has been a significant decrease in both the percentage and absolute number [ Read More ]

Docetaxel Boosts Survival in Hormone-Naive Metastatic Prostate Cancer

Adding docetaxel to standard hormone therapy extends overall survival (OS) by a median of 10 months versus hormone therapy alone in men with newly diagnosed, advanced hormone therapy–naive prostate cancer according to results from the STAMPEDE trial. The survival benefits were more pronounced in metastatic disease and were less certain [ Read More ]

Cabozantinib in Prostate Cancer Patients with Bone Metastasis

Prostate cancer is the most common nondermatologic cancer diagnosed among males in the United States with approximately 233,000 new cases annually. In addition, prostate cancer is the second leading cause of cancer death in men with over 29,000 estimated deaths in 2014.1 Once prostate cancer has metastasized and progressed to [ Read More ]

Predictors of Hormone Responsiveness in Prostate Cancer

Prostate cancer is the most common noncutaneous cancer in men and the second most common cause of cancer-related death.1 Normal prostate cells and prostate cancer cells require the presence of androgen for growth and survival. In advanced prostate cancer, androgen deprivation therapy (ADT), medically or surgically, has been the mainstay. [ Read More ]

Hormonal Therapy for Prostate Cancer: An Oncologist’s Perspective

Over the past few years there has been notable progress in hormonal therapy for prostate cancer. First is the development of drugs that avoid tumor flare, eg, the development of degarelix.1 These drugs decrease the level of testosterone very efficiently in a very short period (3 days). The use of [ Read More ]

Androgen Suppression in Castration-Resistant Prostate Cancer

Prostate cancer is the most frequently diagnosed cancer in men other than skin cancer and is the second-leading cause of cancer death in men in the United States.1,2 An estimated 238,590 new cases of prostate cancer will have occurred in the United States during 2013, with an estimated 29,720 deaths.1,2 [ Read More ]

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