The Lynx Group

AACR

Immune Checkpoint Inhibitors Do Not Increase Mortality in Patients with Cancer and COVID-19

One question on oncologists’ minds recently is whether treatment with immune checkpoint inhibitors in patients with cancer has a negative effect on COVID-19 disease. So far, the data have not shown a deleterious effect, but the definitive answer is unknown. In fact, some experts think immune checkpoint inhibitors may have a positive effect on the virus.

ctDNA May Be a Biomarker for Postsurgery MRD Positivity and Relapse in Patients with NSCLC

Data from the TRACERx lung study suggest that circulating tumor DNA (ctDNA) may be a biomarker for the detection of postsurgical minimal residual disease (MRD) in patients with non–small-cell lung cancer (NSCLC), suggesting which patients are at increased risk for disease relapse and will require more aggressive adjuvant therapy.

RAF Family Inhibitor Has Preliminary Activity in Multiple Types of Tumors

A multitargeted RAF inhibitor demonstrated activity in several types of advanced solid tumors associated with different mutations in the RAF family of genes, results of a preliminary clinical trial showed. Of 29 evaluable patients, 3 had confirmed partial responses to treatment with BGB-283, 1 had an unconfirmed response, and 14 [ Read More ]

Stool DNA Test Performs Well in Community-Based Setting

A noninvasive screening test for colo­rectal cancer demonstrated potential for identifying cancer and advanced adenomas in community-based patients who previously had not followed national screening recommendations.Almost 90% of patients completed the Cologuard stool DNA test when offered the option, and 15% had positive tests that led to referral for diagnostic [ Read More ]

Biologic Agents and Cardiac Toxicity Among Patients with Hematologic Malignancies

Targeted therapies used to treat hematologic malignancies can cause unintended cardiac toxicity in some patients and can lead to cardiac-related mortality, according to study results presented at the American Association for Cancer Research Annual Meeting. “Unanticipated cardiac toxicity occurred in about 4% of patients with hematologic malignancies over a 10-year [ Read More ]

Multivitamin Use During Chemotherapy May Reduce Risk of Peripheral Neuropathy

Multivitamin supplement use was associated with a reduction in chemotherapy-associated peripheral neuropathy in a subanalysis of the SWOG S0221 trial. Patients who were using multivitamins before chemotherapy had 40% less neuropathy, and those using them during or after treatment had a 23% reduced risk. The results were reported at the [ Read More ]

Walking Reduces Markers of Inflammation in Smokers with Lung Cancer

If you can’t get your lung cancer patients to stop smoking, at least encourage them to exercise. That’s the message from research conducted on a huge cohort of individuals in the National Health and Nutrition Examination Survey (NHANES), showing that markers of inflammation were significantly reduced among male smokers with [ Read More ]

To Reduce Breast Cancer Recurrence Risk, Exercise—A Lot!

For protection against breast cancer recurrence, one recently reported study can best be described as “good news, bad news.”At the American Association for Cancer Research Annual Meeting, researchers reported a statistically significant dose response for the effects of physical activity on breast cancer recurrence. The catch is that the effect [ Read More ]

Novel Regimen Outperforms Standard Therapy in HER2 Breast Cancer

An ongoing trial of a novel strategy to evaluate new regimens for early-stage breast cancer has identified another neoadjuvant combination worthy of a phase 3 trial involving patients with HER2-positive disease. The combination of ado-trastuzumab emtansine (T-DM1) and pertuzumab resulted in an estimated pathologic complete response (pCR) rate of 52% [ Read More ]

Chemotherapy Use in Breast Cancer Declines with Gene-Based Assay

Women with clinicopathologic high-risk breast cancer received chemotherapy almost half as often with no increased risk of metastatic recurrence when a cancer gene assay was used to guide decision-making, results of a randomized trial showed. Patients at low risk by the 70-gene MammaPrint assay had a 5-year distant metastasis-free survival [ Read More ]

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