Checkpoint Inhibition of PD-1: The Promise of Pembrolizumab (MK-3475) and Beyond
The idea of harnessing a patient’s own defenses and actively augmenting a deficient immune response to help fight disease has been implemented since the 18th century. Adoption of immunotherapy into clinical practice has been difficult until recently, when many late-stage clinical trials demonstrating an overall survival (OS) advantage in melanoma [ Read More ]