Steven Sorscher, MD; Boris Pasche, MD, PhD, FACP; Shakti Ramkissoon, MD, PhD;

A One Pathway “Two-Different Hit” Hypothesis: Symbiosis in Transformation

November 2016, Vol. 5, No. 9 - Genetics

The Knudson Two-Hit Hypothesis is the accepted common mechanism for transformation in patients with most familial cancer syndromes. A germline deleterious mutation in a tumor suppressor gene (TSG) increases the risk of developing specific malignancies. The gatekeeper event is loss of heterozygosity (LOH) or loss of expression of normal protein [ Read More ]