December 2016, Vol. 5, No. 10 - Genetic Counseling
Parents with inherited cancer mutations often wonder when to disclose results to their children and what affect it will have on them. A recent study examined the impact of a family history of breast cancer or a familial BRCA1/2 mutation on girls aged 11 to 19 years.1 The study included [ Read More ]
August 2016, Vol. 5, No. 6 - Genetic Counseling
Both BRCA1 and BRCA2 mutations have been shown to confer an increased risk for ovarian, fallopian tube, and primary perineal cancer. As a result, guidelines recommend bilateral salpingo-oophorectomy (BSO) upon completion of child bearing and preferably between ages 35 and 40 years as a risk-reducing option.1 However, what has been [ Read More ]
June 2016, Vol. 5, No. 5 - Genetic Counseling
Compared with other cancers, ovarian cancer is relatively rare, accounting for just 1.3% of all new cancer cases in the United States. However, it has a high death rate—the highest of any female reproductive system cancer. Only around 1 in 7 women with ovarian cancer are diagnosed at the local [ Read More ]
May 2016, Vol. 5, No. 4 - Genetic Counseling
The ability to analyze multiple genes at the same time has led to the estimate that 20% to 25% of women with ovarian cancer have an inherited mutation in a cancer-predisposing gene.1 Although this association has been noted for a while, until recently there were not enough data available to [ Read More ]
April 2016, Vol. 5, No. 3 - Genetic Counseling
The number of genes associated with breast cancer risk continues to increase. Recently, through whole exome sequencing, 2 groups of researchers have demonstrated that mutations in RECQL increase the risk of breast cancer.1 The first paper, by Cybulski and colleagues, was published online in Nature Genetics in April 2015, and [ Read More ]
March 2016, Vol. 5, No. 2 - Genetic Counseling
In the past few years, some of the classic phenotypes and associated cancer risk estimates of inherited cancer syndromes have been questioned. This is due partly to increased access to genetic testing as well as to the availability of next-generation sequencing (NGS) panels for inherited cancer. Such panels allow researchers [ Read More ]
February 2016, Vol. 5, No. 1 - Genetic Counseling
Prostate cancer is the most common nondermatologic cancer in males in the United States. Incidence and mortality rates vary significantly between countries. In the United States, the lifetime risk of developing prostate cancer is approximately 1 in 7, with an incidence similar to that of breast cancer. In 2015, it [ Read More ]
October 2015, Vol. 4, No. 5 - Genetic Counseling
Pancreatic cancer represents 3% of new cancer cases each year, with the average age of diagnosis being 71 years.1 The most common type of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC), which originates from exocrine cells. Although pancreatic cancer accounts for a small percentage of cancers each year, its survival [ Read More ]
September 2013, Vol 2, No 6 - Uncategorized
In 2013, approximately 65,000 people will be diagnosed with kidney cancer and two-thirds will be men.1 The term kidney cancer generally refers to any cancer arising in the kidney or renal pelvis. However, this article will focus on the most common type of kidney cancer seen in adults, renal cell [ Read More ]
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