The Lynx Group

Beverly E Barton, PhD


Authored Items

Cytokines as Immune Adjuvants for Treating Cancer

September 2014, Part 3 - Uncategorized

Overview Cytokines are familiar to the oncologist as the glycoprotein messengers of the immune system and beyond. Their role in cancer treatment has been firmly established since the late 1980s, when investigators reported that interleukin (IL)-2 administration plus adoptive transfer of lymphokine-activated killer cells were effective treatment for refractory solid [ Read More ]

IDO: A Target for Cancer Treatment

June 2014, Part 2 - Uncategorized

Immune checkpoints modulate immune responses by providing signals that attenuate T cells. The importance of immune checkpoints in cancer treatment has been underscored by recently approved therapies. For example, ipilimumab is a monoclonal antibody directed against the cytotoxic T-lymphocyte antigen (CTLA)-4. Normally, CTLA-4 would prevent the costimulatory activity of CD80 [ Read More ]

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