Perspectives on Key Presentations in GI Cancer from ASCO-GI 2022: Part I

Rapid Reactions

Rapid Reactions is a video series that provides commentary from key experts summarizing data released at the 2022 American Society of Clinical Oncology Gastrointestinal Cancers Symposium (ASCO-GI) focused on gastric, gastroesophageal, and esophageal cancer. Please join Minsig Choi, MD, from Stonybrook University Cancer Center, as he discusses the following 3 pivotal presentations from ASCO-GI 2022:

  • Updated results of the CheckMate-649 study indicated that nivolumab plus chemotherapy continued to demonstrate clinically meaningful improvement in efficacy with longer follow-up, with no emergence of new safety issues
  • Results of the multicohort phase 1/2 KRYSTAL-1 study indicated that adagrasib monotherapy was well tolerated and demonstrated encouraging clinical activity in pretreated patients with GI tumors harboring a KRAS G12C mutation
  • Updated results of the DESTINY-Gastric01 trial indicated that T-DXd therapy continued to demonstrate overall survival benefit compared with chemotherapy, accompanied by a manageable safety profile, in previously treated patients with HER2-positive advanced gastric cancer or gastroesophageal junction adenocarcinoma

Read the Articles Discussed in the Video

  1. Nivolumab plus Chemotherapy as First-Line Treatment for Advanced Gastric Cancer/Gastroesophageal Junction Cancer/Esophageal Adenocarcinoma: Expanded Analysis from CheckMate 649
  2. KRYSTAL-1: Adagrasib in Previously Treated Patients with Unresectable or Metastatic Pancreatic Cancer and Other Gastrointestinal Tumors with a KRAS G12C Mutation
  3. Improved Survival with Trastuzumab Deruxtecan in Patients with HER2-Positive Advanced Gastric or Gastroesophageal Junction Adenocarcinoma: DESTINY-Gastric01

Breast Cancer, Web Exclusives - October 4, 2018

Less Is More: 6 Months of Trastuzumab Treatment Equivalent to 12 Months in HER2-Positive Breast Cancer

Analysis of the phase 3 randomized clinical trial PERSEPHONE showed that 6 months of treatment with trastuzumab was noninferior to 12 months in terms of disease-free survival, whereas a shorter course of trastuzumab was associated with a 50% reduction in cardiotoxicity.

Gastrointestinal Cancer, Web Exclusives - August 31, 2018

New Clues to Mismatch Repair and PD-1/PD-L1 Status and Survival in Patients with Gastric or Esophageal Cancer

San Francisco, CA—Understanding the complex relationship between the PD-1 receptor, its ligand 1 (PD-L1), and mismatch repair deficiency (dMMR) status may help to improve treatment outcomes in patients with resectable gastric and esophageal cancer, according to a retrospective tissue-based analysis.