Letter from the Editor June 2013

Paul Richardson, MD

Uncategorized

Progress in the treatment of hematologic malignancies has been remarkable over the past decade, primarily due to the introduction of targeted agents, a better understanding of prognostic indicators, and new data on biomarker analysis. There is no doubt that these advances have great potential for improving outcomes; however, hematologists and oncologists who seek to provide state-of-the-art therapy for their patients may be challenged by the rapidly shifting paradigm of care. In 2013, a wealth of new data regarding the treatment of chronic lymphocytic leukemia, chronic myeloid leukemia, non-Hodgkin lymphoma, Hodgkin lymphoma, myelodysplastic syndrome, myelofibrosis, and multiple myeloma will be presented at major scientific meetings throughout the world. In this “Faculty Perspectives†newsletter series, we will feature highlights from several of these meetings, along with perspectives from renowned thought leaders in the field, which will provide valuable practice implications for the management of patients with hematologic malignancies.

Sincerely,

Paul Richardson, MD
RJ Corman Professor of Medicine
Harvard Medical School
Clinical Director
Jerome Lipper Center for Multiple Myeloma
Dana-Farber Cancer Institute
Boston, Massachusetts

Uncategorized - January 5, 2016

Trabectedin: a DNA-Binding Agent That Covalently Interacts with the Minor Groove of the DNA Double Helix

Trabectedin (ET-743) is a marine alkaloid isolated from the Caribbean tunicate Ecteinascidia turbinata, with a chemical structure characterized by 3 fused tetrahydroisoquinoline rings.1 Trabectedin binds to the minor groove of DNA and alkylates guanine at the N2 position, bending the helix toward the major groove.2,3 In this manner, it is [ Read More ]

Best Practices: Biomarkers - August 16, 2022

Best Practices: Biomarkers and Treatment Selection in the Management of Advanced NSCLC

Wallace Akerley, MDProfessor of Medicine Thoracic Oncology Huntsman Cancer Institute at University of Utah Salt Lake City, UT Katie Kerrigan, DO Assistant Professor of Internal Medicine Division of Medical Oncology Huntsman Cancer Institute at University of Utah Salt Lake City, UT Introduction Immune checkpoint inhibitors (ICIs) have revolutionized the treatment [ Read More ]