May 2012, Vol 1, No 1

Personalized Medicine in Oncology: The Landscape of the Next Generation of Cancer Care

Personalized medicine. Innovation’s 21st century poster child … and bastion of medical uncertainty, wishful thinking, and unfulfilled aspirations striking terror into the ledger sheets of payers unable to cope with conventional (empirical) medicine. Mastering personalized medicine (PM) requires an awareness of its governing dynamics, understanding that it exists in many [ Read More ]

Robert E. Henry

Publications

Global Biomarkers Consortium — Implementing the Promise of Personalized Cancer Care

The inaugural conference of the Global Biomarkers Consortium brought together an international panel of oncology experts to explore the rapidly evolving field of biomarker research. Cochairs of the event were Hope S. Rugo, MD, director of Breast Oncology and Clinical Trials Education at the University of California San Francisco, and [ Read More ]

Conference Correspondent

Immunotherapy for Advanced Prostate Cancer May Be Underutilized

Sipuleucel-T for metastatic castrate-resistant prostate cancer (mCRPC) offers a novel immunotherapy treatment option for a subset of patients, but the drug could be helping far more men than actually receive it, according to a speaker at the 37th Annual Congress of the Oncology Nursing Society. Sipuleucel-T, which activates T cells [ Read More ]

Caroline Helwick

Conference Correspondent

New Agents Prove Potent Against HER2-Positive Breast Cancer

Trastuzumab changed the course of HER2-positive breast cancer, and future anti-HER2 therapies may have an even greater impact, said Kristine Abueg, RN, MSN, OCN, clinical research nurse at Kaiser Permanente in Roseville, California, who discussed “What’s New in HER2?” at the 37th Annual Congress of the Oncology Nursing Society. In [ Read More ]

Caroline Helwick

Conference Correspondent

What Oncologists Need to Know About 7 New Agents

Oncologists should understand the characteristics of 7 emerging drugs and biologics that should improve patient care. At the 2012 Pharmacy Program held during the 17th Annual Conference of the National Comprehensive Cancer Network (NCCN) in Hollywood, Florida, Van Anh Trinh, PharmD, of the University of Texas MD Anderson Cancer Center, [ Read More ]

Caroline Helwick

Conference Correspondent

Clinical Trial Designs for Biomarker Evaluation

The translation of clinical research to practice in the field of oncology has been slow despite a growing understanding of the genetic and molecular basis of this disease.1 a myriad of factors impact this slow pace of progress, issues relating to clinical trial design play a significant role, including patient [ Read More ]

Biomarkers

Accelerating Personalized Medicine Approaches in Multiple Myeloma: An Interview With Kathy Giusti and Deborah Dunsire, MD

In the attempt to bring personalized treatment to multiple myeloma patients, the Multiple Myeloma Research Foundation (MMRF) began its CoMMpassSM (Relating Clinical Outcomes in Multiple Mye lo ma to Personal Assessment of Genetic Profile) study – a landmark study designed to uncover the molecular segments and variations in multiple myeloma. [ Read More ]

Interviews

Precision Medicine: Applying Predictive and Prognostic Indices to Risk-Adapted Treatment Selection

The shift from dose-intense standard chemotherapy to therapies targeting specific signaling pathways, molecular targets, or elements of the tumor microenvironment presents a number of challenges to the oncology professional and the patient. Cancer diagnosis and treatment requires precision in the diagnostic evaluation (asking all the critical diagnostic questions at the [ Read More ]

Sandra Kurtin, RN, MS, AOCN, ANP-C

Biomarkers

Cancer Care Grand Rounds

A persistent health-care myth is that the U.S. system is uniquely wasteful versus the European countries that spend far less per patient as a result of tight government control. Only the establishment experts who spread this myth will be surprised, but new research shows American patients are often getting more [ Read More ]

Pharmacoeconomics