June 2014, Vol 3, No 4

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PMO and the PMC – A Collaboration to Advance Precision Medicine

Kristin Siyahian

The Last Word

Introducing Dr Edward Abrahams, President of PMC, as the Author of The Last Word

Since the inception of Personalized Medicine in Oncology (PMO), we have offered the department The Last Word in which we sum up thoughts on various overriding themes in the world of personalized medicine. In this thought-provoking column we have discussed the impact on oncology care of various forces in our culture – from the Affordable Care Act to a star’s decision to proceed with double mastectomy.

Also during our publishing tenure, we have established a partnership with the Personalized Medicine Coalition (PMC). PMC exists for many of the same reasons as PMO – personalized medicine will (and is) changing the way drugs are developed and medicine is prescribed. The use of new breakthrough methods of molecular analysis to better manage a patient’s disease or predisposition to a disease will transform medicine. Yet the regulatory and financial systems that will support personalized medicine are not yet in place. While PMO exists to educate readers about the advances in personalized medicine that will improve patient care, the mission of PMC is to build a foundation for the advancement of personalized medicine as a viable solution to the challenges of efficacy, safety, and cost. To this end, PMC was launched in 2004 to educate the public and policymakers and to promote new ways of thinking about healthcare. Today, PMC represents a broad spectrum of more than 225 innovator, academic, industry, patient, provider, and payer communities, as they seek to advance the understanding and adoption of personalized medicine concepts and products for the benefit of patients.

As a part of our partnership, we are pleased to have the president of the PMC, Edward Abrahams, PhD, as the new author of The Last Word. By way of background, prior to serving as president of the PMC, Dr Abrahams was executive director of the Pennsylvania Biotechnology Association, where he spearheaded the successful effort that led to the Commonwealth of Pennsylvania’s investment of $200 million to commercialize biotechnology in the state. Earlier he had been assistant vice president for federal relations at the University of Pennsylvania and held a senior administrative position at Brown University. Dr Abrahams worked for 7 years for the US Congress, including as a legislative assistant to Senator Lloyd Bentsen, an economist for the Joint Economic Committee under the chairmanship of Representative Lee Hamilton, and as an American Association for the Advancement of Science Congressional Fellow for Representative Edward J. Markey. The author of numerous essays, Dr Abrahams serves on the editorial board of Personalized Medicine. He has also taught history and public policy at Brown University and the University of Pennsylvania.

The next issue of PMO will feature Dr Abrahams’ inaugural column, in which he will present an overview of PMC’s signature and soon-to-be-launched document, The Case for Personalized Medicine (4th edition). All of us at PMO are looking forward to Dr Abrahams’ contributions to this department and are confident they will be of great interest to our readers.

Uncategorized - June 30, 2014

Multitargeted Kinase Inhibitor Shows Promising Results for Breast Cancer Subgroup

HER2+/HR– Breast Cancer Subtype Identified as Biomarker Signature for Neratinib Use A multitargeted kinase inhibitor met criteria for a phase 3 clinical trial in breast cancer after statistical modeling of clinical data showed a high probability of success versus standard therapy for patients with HER2-positive/hormone receptor (HR)-negative (HER2+/HR–) disease. Neoadjuvant [ Read More ]

Uncategorized - June 30, 2014

Prospects for Personalization of Medicine Lie in Evidence Thresholds

Although targeted drug development and testing is clearly transforming medicine, resistance to greater uptake of personalized medicine includes a shift in the evidence threshold in personalized testing and drawbacks to the delivery system, including the cost of tests, said Peter Bach, MD, at the Fourth Annual Conference of the Association [ Read More ]