July 2015, Special ASCO Edition

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Sharing the Best of ASCO

Letter to Our Readers

Dear Colleague,

Each year, we look forward to the American Society of Clinical Oncology (ASCO) Annual Meeting where the oncology community gathers to review the past year and discuss the lessons and successes that will impact the lives of patients. The value in gathering is not only in sharing what we have learned over the past year, but also in renewing our enthusiasm for our chosen profession and enabling us to provide the best in care for our patients.

This year, we are pleased to offer our readers highlights from ASCO in this special edition of Personalized Medicine in Oncology (PMO). It comes as no surprise that the talk of the meeting centered on the progress being made in immunotherapeutic approaches to the treatment of cancers. You will find several feature articles reviewing the topic to include updates in several disease states, biomarkers for immunotherapies, and combination strategies with targeted therapies.

We also turn our attention to a host of other topics, most notably the progress in our understanding of genetics and biomarkers and of lung, prostate, breast, thyroid, kidney, and other cancers. Additionally, the format of this special edition of PMO allows us to expand our focus beyond that of personalized medicine to targeted therapies, biomarkers, and immunotherapies. In this supplement, we explore the topic of value-based care and associated costs. We address this topic in several articles in the hope of providing you a full perspective.

Thank you for your loyal readership. It is our mission to provide you with the most compelling and important information to help you bring the best care to those in need.

Sincerely,

Al B. Benson III, MD, FACP, FASCO
Coeditor in Chief
Personalized Medicine in Oncology

Uncategorized - August 13, 2015

Urine Assays Detect Early Mutations in Patients with Advanced Cancers

An assay that measures circulating tumor DNA (ctDNA) in the urine can detect mutations in patients with advanced cancers. In one study, tracking cell-free DNA mutations in the urine from patients with refractory cancers found that low-frequency KRAS mutations were present in about 80%, said Filip Janku, MD, PhD. “We [ Read More ]

Immunotherapy - August 13, 2015

Pembrolizumab in Colorectal Cancer: Can Benefit Be Predicted?

New to the programmed death-1 (PD-1) inhibitor arena is colo­rectal cancer, and for this tumor it may be possible to predict which patients will benefit from these drugs. In a phase 2 study of patients with colorectal cancer treated with pembrolizumab, the presence of mismatch repair (MMR) deficiency within the [ Read More ]