August 2015, Vol 4, No 4

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Showcasing the Success of Precision Medicine

Letter to Our Readers

Dear Colleague,

In this issue of Personalized Medicine in Oncology (PMO), we are pleased to offer a wealth of information showcasing the success of precision medicine. Breakthroughs in screening, diagnosing, and treating patients based on the specific biology of individuals and their tumors have impacted our ability to turn some cancers from an acute disease to a chronic one and thereby extend the life of patients.

In this and subsequent issues, we highlight the proceedings from our own PMO Live Annual Meeting, which took place in Seattle, WA, July 22-25, 2015. PMO Live is a joint meeting of the Global Biomarkers Consortium and the World Cutaneous Malignancies Congress focusing on personalized medicine techniques in oncology. Expert faculty and attendees gathered at the meeting to explore the application of new diagnostics, biomarkers, and drug regimens, in addition to the rapid changes to the healthcare system and their impact on oncology care and access for patients.

In our Interview with the Innovators, you will meet Drs Dixie-Lee Esseltine and George Mulligan of the Takeda Company. They provide insights to the impact of oral oncolytics for those patients with multiple myeloma.

Also in this issue of PMO, we highlight a review from Drs Brian T. Helfand and Charles B. Brendler entitled “A Genetic-Based Approach to Individualized Prostate Cancer Screening and Treatment,” as well as important presentations from the American Society of Clinical Oncology.

Thank you so much for your loyal readership. It is a pleasure to serve you in our quest to improve the lives of patients.

Sincerely,

Al B. Benson III, MD, FACP, FASCO
Coeditor in Chief
Personalized Medicine in Oncology

Mechanism of Action/Pathway Profiles - August 24, 2015

Molecular Pathways in Cancer Are Increasingly Being Exploited

Molecular pathways in cancer can be exploited for therapy, and sensitizing genetic aberrations are the ideal targets, said Alex Adjei, MD, PhD, at PMO Live 2015. Cancer cells have to evade a number of stresses to grow. They are complex and live in a toxic environment, but somehow they manage [ Read More ]

Mechanism of Action/Pathway Profiles - August 24, 2015

Case Presentation: Targeted Therapy in Metastatic Melanoma

The management of melanoma has entered an era of biomarker-driven targeted therapy and immunotherapy. The following case, presented by Sanjiv S. Agarwala, MD, at PMO Live 2015, illustrates the 2015 approach to the management of metastatic melanoma. Case: Metastatic Melanoma A 56-year-old female with a history of T2N2b melanoma and [ Read More ]