August 2014, Vol 3, No 5
PMO: Advancing the Practitioner’s Ability to Provide Customized Care to PatientsLetter to Our Readers
Until recently, cancer treatment relied solely on histological diagnosis for determining systemic therapy. Aside from considerations related to a patient’s underlying comorbidities and performance status, there was minimal deviation from an organ-of-origin–based treatment strategy. This relatively primitive understanding of malignancy failed to exploit biological and molecular differences within each cancer type to allow for selection of a more rational therapy and thereby improve patient outcomes. However, exciting strides are currently being made in the field of cancer research and treatment, both with solid tumors and hematologic malignancies, and the available treatment options and physician’s ability to tailor therapies to individual patients have markedly expanded.
Our quest is to advance the practitioner’s ability to provide customized care to his or her patients. We will accomplish this by focusing on technologies and therapeutics available to clinicians and their impact on diagnostic, prognostic, and predictive medicine.
In this issue, you will find an in-depth article on immune checkpoint blockades in metastatic melanoma as well as an update on RAS analysis in colon cancer. The information presented in both articles is critical to oncologists on the front-lines of treating these diseases.
Also in this issue, you’ll hear from the president of the Personalized Medicine Coalition (PMC), Dr Edward Abrahams – the new host of our department The Last Word. Dr Abrahams provides an overview of the signature document of the PMC, The Case for Personalized Medicine.
Thank you for your loyal readership. On behalf of the entire editorial board, it is our pleasure to serve you.
Al B. Benson III, MD
Coeditor in Chief
Personalized Medicine in Oncology
For the second-line treatment of chronic lymphocytic leukemia (CLL), ibrutinib improved not only progression-free survival (PFS) but also overall survival (OS), the phase 3 RESONATE study showed. In conjunction with the ASCO presentation, the study was published online in the New England Journal of Medicine. “Ibrutinib beat a standard comparator [ Read More ]
In breast cancer patients with bone metastasis, less frequent infusion of zoledronic acid was as effective as the standard monthly dose, the randomized OPTIMIZE-2 study showed. “We found that less frequent treatment may reduce the risk of serious side effects, with the additional benefits of reduced inconvenience to the patient [ Read More ]