April 2015, Vol 4, No 2

The Ultimate Target of Personalized Oncology Treatment: Improving the Lives of Our Patients

Dear Colleague, The landscape of cancer care has evolved tremendously over the past decade in every aspect: research targets, available treatments, management strategies, even the makeup of the oncology multidisciplinary team. The publishers of Personalized Medicine in Oncology (PMO) recognize the importance of providing information for the entire oncology team [ Read More ]

Letter to Our Readers, Mechanism of Action/Pathway Profiles

Confirming Diagnoses and Identifying Biomarkers Linked to Targeted Treatments with the bioT3 Approach

The current generation of oncologists has witnessed great advances in our understanding of tumor biology and biomarkers linked to treatments. Those advances started with research, but disseminating this information can be difficult given the myriad of obstacles in adoption to practice. The science behind these advances is fascinating and excites [ Read More ]

Ralph V. Boccia, MD, FACP

Interview with the Innovators, Mechanism of Action/Pathway Profiles

Two Cases of Triple-Hit Lymphoma: A Call for Imperative MYC, BCL2, and BCL6 Testing by FISH in Aggressive Lymphomas

Remission in aggressive B-cell lymphomas is increasingly linked to complex karyotypes and gene rearrangements that often portend aggressive behavior and resistance to standard therapy. An understanding of lymphoma cytogenetics has lagged behind that of leukemia, in which pretreatment karyotype constitutes an independent prognostic determinant for attainment of complete remission. In [ Read More ]

Joshua Brody, MD

Hematological Malignancies, Mechanism of Action/Pathway Profiles

Biomarkers of the mTOR Pathway in Breast Cancer

It is estimated that 232,670 women will have been diagnosed with breast cancer in 2014 and 40,000 women will have died of the disease. Approximately 89% of women with breast cancer of any stage will survive 5 years; when breast cancer is diagnosed at an early stage the prognosis is [ Read More ]

Ruth O’Regan, MD

Breast Cancer

Cabozantinib in Prostate Cancer Patients with Bone Metastasis

Prostate cancer is the most common nondermatologic cancer diagnosed among males in the United States with approximately 233,000 new cases annually. In addition, prostate cancer is the second leading cause of cancer death in men with over 29,000 estimated deaths in 2014.1 Once prostate cancer has metastasized and progressed to [ Read More ]

Leonel F. Hernandez-Aya, MD

Prostate Cancer

AR-V7 Predicts Chemotherapy Sensitivity in Metastatic Prostate Cancer

New biomarker to guide treatment decisions on the horizon Experts are hopeful that the field of prostate cancer will soon be catching up to breast cancer and some other tumor types with regard to genomic markers. A study featured at the 2015 Genitourinary Cancers Symposium suggests that the androgen receptor [ Read More ]

2015 Genitourinary Cancers Symposium

No Role for Adjuvant Sorafenib or Sunitinib in Locally Advanced Kidney Cancer

Use of adjuvant sorafenib and sunitinib failed to extend disease-free survival (DFS) in patients with locally advanced kidney cancer at high risk of recurrence, according to initial results from the ASSURE study presented at the meeting. ASSURE is the first and largest study of adjuvant vascular endothelial growth factor (VEGF) [ Read More ]

2015 Genitourinary Cancers Symposium

What Is a Navigator?

You have just been diagnosed with cancer, and one of the first people you meet on your healthcare team is introduced as a navigator. “A what?” you think. “I need doctors, not a GPS!” But over time, you will realize this person is a great guide. Because they are positioned [ Read More ]

Sharon S. Gentry, RN, MSN, AOCN, CBCN

Patient Navigation

President Obama’s Bet on Personalized Medicine

“I want the country that eliminated polio and mapped the human genome to lead a new era of medicine, one that delivers the right treatment at the right time.” So said the president of the United States in his State of the Union Address on January 20, 2015. By calling [ Read More ]

Edward Abrahams, PhD

The Last Word