September 2015, Vol. 2, No. 5
Enthusiasm Mounts as Immunotherapy Continues to Play a Positive Role in Many Disease StatesLetter to Our Readers
I am writing to you with a renewed enthusiasm for the field of immunotherapy in oncology after hosting the World Cutaneous Malignancies Congress this summer! This educational opportunity is an event of which I am proud, as world-renowned experts convene to present the most up-to-date information on the treatment of cutaneous malignancies. It is our great pleasure to bring this information to you in hope of enhancing your ability to provide the best care possible to your patients. In these pages you will read about the molecular biology of cutaneous malignancies as well as emerging approaches to treating advanced melanoma, basal cell carcinoma, cutaneous T-cell lymphoma, and Merkel cell carcinoma.
You will read continuing coverage from other meetings as well, where immunotherapy continues to make headlines and impact our understanding of how best to care for our patients.
We continue our series of immunotherapy in specific disease states. In this issue, you will find our in-depth report on immunotherapy in breast cancer to include a discussion of vaccines, checkpoint inhibitors, T-cell therapy, and antibodies.
Addressing the business aspect of the immunotherapy field, we are pleased to offer an editorial by Rachel Laign, PhD, and Olivier Lesueur of Bionest Partners on the timeli- ness of partnerships between developers of targeted therapies and immunotherapies and the potential clinical impact.
Please enjoy this issue; I hope your enthusiasm for the art of medicine continues to grow.
Sanjiv S. Agarwala, MD
Editor in Chief
Immunotherapy in Oncology
There is excitement about immunotherapy for the treatment of several types of tumors, and the list of cancers amenable to this approach is expanding. In addition to the programmed death-1 (PD-1) and its ligand 1 (PD-L1) immunotherapies, chimeric antigen receptor T (CAR-T)-cell therapy is also garnering much interest, especially in [ Read More ]
Emerging concepts in the treatment of melanoma include new definitions for stage I/II and stage III disease, new surgical paradigms that incorporate systemic neoadjuvant therapy for advanced disease, and locoregional treatment with intralesional therapies that have both local and distant effects, said presenters at the 2015 World Cutaneous Malignancies Congress. [ Read More ]