November 2015, Vol. 2, No. 6

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Exploring the Possibilities of Manipulating the Immune System to Improve Outcomes

Sanjiv S. Agarwala, MD

Letter to Our Readers

Dear Colleague,

We are pleased to continue our in-depth coverage of the role of immunotherapy in oncology care. Immunotherapy has long captured the interest of researchers combating disease, and none more so than oncology researchers. Recent advances in immunotherapy have made headlines and been the main attraction at association meetings. It is our mission to explore the topic diligently and thoroughly in the hope of providing our readership with information that will help improve and extend the life of patients with cancer.

In this issue, we present an interview with Elizabeth I. Buchbinder, MD, of Dana-Farber Cancer Institute about her research addressing the question of optimal sequencing of immunotherapeutic agents for patients with metastatic melanoma and metastatic renal cell carcinoma. Her research specifically addresses the efficacy and safety of high-dose interleukin-2 given after CTLA-4–targeting agents or other immune checkpoint blockade agents.

We also provide an in-depth article about targeting PD-1 and its ligand PD-L1. It is our hope this report provides increased awareness about the possibilities of manipulating the immune system to effectively combat cancers.

As always, we survey the vast amounts of information coming out of association meetings and bring you relevant and potentially clinically impactful stories. In this issue, you will read about important immuno-oncology information from the European Cancer Congress, American Society of Gene and Cell Therapy, International Lung Cancer Congress, and our own World Cutaneous Malignancies Congress.

Thank you for your loyal readership. We wish you success in your quest to provide the best care for your patients and hope your awareness and understanding of immunotherapy options is enhanced by our offerings.

Best regards,

Sanjiv S. Agarwala, MD
Editor in Chief
Immunotherapy in Oncology

European Cancer Congress - November 9, 2015

Two New Options for Renal Cell Carcinoma

Patients with advanced, pretreated renal cell carcinoma (RCC), who have limited treatment options, received good news from 2 important practice-changing trials presented as late-breakers at the recent 2015 European Cancer Congress (ECC)—CheckMate 025 and METEOR. CheckMate 025 found a survival benefit for nivolu­mab over standard everolimus therapy in previously treated [ Read More ]

Immune Checkpoint Blockade - November 9, 2015

Targeting Programmed Death-1 (PD-1) and Its Ligand (PD-L1)

Immunologic checkpoint blockade with antibodies targeting PD-1 or one of its ligands, PD-L1, is showing promise as a method for reversing cancer immunosuppression and thereby promoting immune responses against several cancer types.1 While the first checkpoint inhibitor approved by the FDA in 2011 was ipilimumab, an antibody that targets cytotoxic [ Read More ]