May 2015, Vol. 2, No. 3
Exploring Advances in ImmunotherapyLetter to Our Readers
In this issue of Immunotherapy in Oncology (ITO), we continue to explore the many facets of immunotherapy, reaching beyond the basic science to bring you the practical implications of its usefulness. We are pleased to report that the FDA recently approved nivolumab injection, for intravenous use, for the treatment of patients with metastatic squamous non–small cell lung cancer with progression on or after platinum-based chemotherapy. This is good news, as nivolumab, a PD-1 (programmed death-1 receptor) therapy, demonstrated improved overall survival in this population. In light of this advance, we present additional articles exploring the need for immunotherapy options in lung cancer, specifically “The Need for Immunotherapeutic Approaches for Lung Cancer” and “Immuno-Oncology Combination
Approaches for Lung Cancer”. We will continue to explore this topic in future
issues of ITO.
Also of interest is the business side of immunotherapy. In our Interview with the Innovators feature, titled “The Commercialization Process of Immunotherapies: An Interview with Olivier Lesueur and Rachel Laing, PhD,” we had the pleasure of talking with two experts from a consulting firm that specializes in bringing products to market. They compare the impact of immunotherapies in the current day to what chemotherapy agents were to cancer care in the 1970s. This comparison isn’t lost on pharmaceutical companies, who are focused on commercializing immunotherapy agents as quickly as possible.
Also in this issue, we present articles from meetings around the country monitoring the progress of immunotherapies. From FDA approvals to biomarkers, you’ll find an array of the most recent, groundbreaking events from the immunology field. We are greatly encouraged by the advances in cancer treatment that immunotherapy affords us, and it is our sincere hope this information assists you in providing the best care for your patients. We are pleased to be your source for information, and as always, we thank you for being part of our reading community.
Sanjiv S. Agarwala, MD
Editor in Chief
Immunotherapy in Oncology
With the advent of new immunotherapeutic agents, including checkpoint inhibitors that target the programmed death-1 (PD-1) pathway and the cytotoxic T-lymphocyte antigen 4 (CTLA-4) pathway, investigations are being conducted to elucidate the potential combination of various therapies and their possible synergistic activity with chemotherapy Immune checkpoint blockade with monoclonal antibodies [ Read More ]
PROSTVAC plus Immune Checkpoint Inhibitors: Evidence of Improved Overall Survival in Prostate Cancer
The combination of active immunotherapy and immune checkpoint inhibitors shows signs of improved overall survival (OS) in patients with prostate cancer, according to data presented at the 2015 Genitourinary Cancers Symposium. “The comparison of 3 independent trials of PROSTVAC active immunotherapy provides hypothesis-generating data that the addition of an immune [ Read More ]