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BRAF Mutations: An Old Oncogene and a New Target in Non–Small Cell Lung Cancer

Lung carcinoma has been the leading cause of cancer deaths in the United States and worldwide despite advances in chemotherapy.1,2 Management of non–small cell lung cancer (NSCLC) has evolved significantly since 2004, when mutations in epidermal growth factor receptor (EGFR) were found to be the determining factor of response to [ Read More ]

PROSTVAC plus Immune Checkpoint Inhibitors: Evidence of Improved Overall Survival in Prostate Cancer

The combination of active immunotherapy and immune checkpoint inhibitors shows signs of improved overall survival (OS) in patients with prostate cancer, according to data presented at the 2015 Genitourinary Cancers Symposium. “The comparison of 3 independent trials of PROSTVAC active immunotherapy provides hypothesis-generating data that the addition of an immune [ Read More ]

Cell Cycle Progression Test Impacts Treatment Decisions

The cell cycle progression (CCP) test has the power to alter treatment decisions. Results from a prospective registry of newly diagnosed patients with prostate cancer showed that the CCP risk score led to an increase (12%) or decrease (31%) in actual treatment administered in 44% of patients, according to data [ Read More ]

Renal Cell Carcinoma Roundup: Immune checkpoint inhibitors show promise

A new class of cancer therapies has set its sights on immune checkpoints. A trio of studies presented at the 2015 Genitourinary Cancers Symposium offered a glimpse into the evolving landscape of treatment for metastatic renal cell carcinoma (mRCC), and the programmed death ligand 1 (PD-L1) and its receptor, programmed [ Read More ]

PD-L1: Promising MIUC Therapy for cNAC Nonresponders

There’s hope for patients with muscle-invasive urothelial carcinoma (MIUC) who do not respond to cisplatin-based neoadjuvant chemotherapy (cNAC). According to data presented at the 2015 Genitourinary Cancers Symposium, patients with MIUC who are nonresponders to cNAC fare worse than patients undergoing radical cystectomy (RC) alone, but both groups exhibited similar [ Read More ]

Immuno-Oncology Combination Approaches for Lung Cancer

With the advent of new immunotherapeutic agents, including checkpoint inhibitors that target the programmed death-1 (PD-1) pathway and the cytotoxic T-lymphocyte antigen 4 (CTLA-4) pathway, investigations are being conducted to elucidate the potential combination of various therapies and their possible synergistic activity with chemotherapy Immune checkpoint blockade with monoclonal antibodies [ Read More ]

No Role for Adjuvant Sorafenib or Sunitinib in Locally Advanced Kidney Cancer

Use of adjuvant sorafenib and sunitinib failed to extend disease-free survival (DFS) in patients with locally advanced kidney cancer at high risk of recurrence, according to initial results from the ASSURE study presented at the meeting. ASSURE is the first and largest study of adjuvant vascular endothelial growth factor (VEGF) [ Read More ]

AR-V7 Predicts Chemotherapy Sensitivity in Metastatic Prostate Cancer

New biomarker to guide treatment decisions on the horizon Experts are hopeful that the field of prostate cancer will soon be catching up to breast cancer and some other tumor types with regard to genomic markers. A study featured at the 2015 Genitourinary Cancers Symposium suggests that the androgen receptor [ Read More ]

Bristol-Myers Squibb to Expand Its Immuno-Oncology Pipeline with Agreement to Acquire Flexus Biosciences, Inc

Bristol-Myers Squibb Company and Flexus Biosciences, Inc announced today the companies have signed a definitive agreement under which Bristol-Myers Squibb will acquire all of the outstanding capital stock of Flexus, a privately held biotechnology company focused on the discovery and development of novel anticancer therapeutics. The transaction has a potential [ Read More ]

PD-L1 Inhibitor Pembrolizumab Produces Good Responses in Advanced Gastric Cancer

Add gastric cancer to the list of cancers that respond to immunotherapy. In patients with advanced gastric cancer who express programmed cell death (PD)-1 ligand 1 (PD-L1), the humanized monoclonal antibody pembrolizumab demonstrated robust antitumor activity and an acceptable safety profile, according to updated results presented at the 2015 Gastrointestinal [ Read More ]

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