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Women With Triple-Negative Breast Cancer Highly Likely to Carry BRCA1 Gene

Triple-negative breast cancer (TNBC) was strongly associated with BRCA1 status, but not with BRCA2 status, in a large study of medically insured women. The study showed that the number of patients with BRCA mutations with a TNBC profile is statistically significant. The authors of this poster, presented at the 2012 [ Read More ]

In Colon Cancer, Genomic Classifiers Aid in Prognosis

Genomic classifiers – in particular, ColoPrint and MSI-Print, and best when combined – can identify high-risk subsets among surgically resected stage II and stage III colon cancer patients, MD Anderson Cancer Center researchers reported at the 2013 GI Cancers Symposium. “The combination of ColoPrint and MSI-Print improves the prognostic accuracy [ Read More ]

Progress in Personalized Approaches to Colorectal Cancer

Advances in the understanding of the molecular basis of colorectal cancer were featured at a pre-meeting Press Cast for the 10th Annual GI Cancers Symposium held January 24-26, 2013. Three separate presentations focused on: a new molecular classification system for colorectal cancer; gene expression profiling of circulating tumor cells as [ Read More ]

Applying Personalized Medicine in the Overall Healthcare Environment

Dear Reader, Welcome to the second year of publication of Personalized Medicine in Oncology (PMO)! We launched this journal with the goal of providing the practicing oncologist with a translational guide to personalized medicine’s research advances and system improvements that bring targeted treatment into practice, thereby transforming personalized medicine from [ Read More ]

Personalized Medicine Highlights From ASH 2012

Hematologic oncology is a fertile field for exploration of new targets for drug therapy. Below are summaries of presentations from the 54th Annual Meeting of the American Society of Hematology (ASH) on some new targeted therapies for hematologic malignancies currently in phase 2 testing. Quizartinib: FLT3 Inhibitor in AML Quizartinib, [ Read More ]

The Drawn Out Process of the Medical Lawsuit

She was one of the most highly sought radiologists in her hospital, a doctor with the uncanny ability to divine the source of maladies from the shadows of black and white X-ray films. But one afternoon my colleague revealed that she had been named in a lawsuit, accused of overlooking [ Read More ]

Genetic Targets Identified in Triple-Negative Breast Cancer

Triple-negative breast cancer carries a poor prognosis compared with other types of breast cancer because it lacks 3 treatment targets that occur in other types of breast cancer (estrogen receptor, progesterone receptor, and HER2). But triple-negative breast cancer has potential genetic targets of its own, according to a study presented [ Read More ]

Activating HER2 Mutations Found in HER2-Negative Patients

Approximately 4000 breast cancer patients in the United States harbor HER2 mutations amenable to treatment with anti-HER2 therapy but are not receiving it because they are not HER2-positive on fluorescence in situ hybridization or immunohistochemical testing. However, genomic sequencing can identify patients with these mutations, who are likely to benefit [ Read More ]

Stereotactic Body Radiation Therapy Is Effective, Cost Saving, and Convenient for Patients With Prostate Cancer

In the United States right now, intensity-modulated radiation therapy (IMRT) has largely replaced 3-D conformal radiation therapy as the technique of choice for most patients with organ-confined prostate cancer treated with radiation as primary therapy. Other techniques in use include brachytherapy, and at some centers proton beam therapy is being [ Read More ]

Memantine Delays Cognitive Decline in Patients With Brain Metastases Treated With Whole-Brain Radiation

Memantine delayed cognitive decline in patients treated with whole-brain radiation therapy (WBRT) for brain metastases, according to results of a randomized phase 3 trial presented at the 54th Annual Meeting of ASTRO. Cognitive decline is common with WBRT, occurring in 50% to 60% of patients 4 months following radiation treatment. [ Read More ]

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