Genitourinary Cancers Symposium

PD-L1 Inhibitor Has Strong Showing in Metastatic Urothelial Cancer

Patients with previously treated metastatic urothelial cancer had response rates that exceeded historical standards when treated with an investigational immunotherapeutic agent, updated results from a large phase 2 study showed.Treatment with the programmed death-1 ligand 1 (PD-L1) inhibitor atezolizumab led to an overall response rate of 15% in 311 patients, [ Read More ]

No Benefit from Nephrectomy in High-Risk RCC with Thrombus

High-risk patients with metastatic renal cell carcinoma (RCC) and venous tumor thrombus derived no benefit from cytoreductive nephrectomy and should be evaluated for clinical trials of systemic therapy, a retrospective multicenter review suggested.Patients with thrombus above the diaphragm had a median overall survival of 6.8 months after surgery, about a [ Read More ]

Reirradiation of Pelvic Area Is Safe and Improves Quality of Life

Experience at a high-volume center suggests that reirradiation of the pelvis for cancer recurrence or second genitourinary (GU) malignancy is safe in patients with advanced cancer and can achieve excellent and durable palliation of symptoms without causing severe radiation-induced morbidity. These patients are typically near the end of life, and [ Read More ]

Cabozantinib Improves Standard of Care for Second-Line Treatment of Advanced Kidney Cancer

Cabozantinib achieved superior progression-free survival (PFS) versus standard treatment with everolimus in patients with previously treated advanced kidney cancer in an updated analysis of the phase 3 METEOR trial reported at the Genitourinary Cancers Symposium. In addition, a strong trend toward overall survival (OS) favored cabozantinib at an interim analysis, [ Read More ]

Regular Aspirin Use Reduces the Risk for Prostate Cancer Death

The regular use of aspirin reduces the incidence of and risk for death from lethal prostate cancer according to the results from a large observational study reported at the Genitourinary Cancers Symposium. For the purposes of this study, lethal prostate cancer was defined as metastatic disease or prostate cancer–specific death.Aspirin [ Read More ]

Adjuvant Chemoradiotherapy May Provide Benefit in Locally Advanced Bladder Cancer

In the United States, the standard of care for locally advanced bladder cancer after radical cystectomy is to “consider” adjuvant chemotherapy and adjuvant radiation. In a 3-arm randomized trial, adjuvant radiation therapy alone or combined with chemotherapy (ie, chemoradiotherapy) did not significantly improve disease-free survival (DFS) compared with adjuvant chemotherapy [ Read More ]

Liquid Biopsy Characterizing CTCs Can Aid in Treatment Selection

A “liquid biopsy” using phlebotomy blood samples can identify phenotypes and genomic characteristics of circulating tumor cells (CTCs) that may help personalize treatment selection for men with advanced prostate cancer.“Hormonal agents prolong the lives of men with castrate-resistant prostate cancer. The optimal sequence of agents to maximize survival is unknown. [ Read More ]

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