ESMO 2016

Pembrolizumab plus Chemotherapy Doubled Response Rate Over Chemotherapy Alone in NSCLC

With the success of programmed death-1 (PD-1) and PD-1 ligand 1 (PD-L1) inhibitors in non–small cell lung cancer (NSCLC), attention has focused on how best to combine these immunotherapies, and one question has been whether they can be safely and effectively combined with standard chemotherapy. Combining pembrolizumab with a standard [ Read More ]

Practice-Changing Study Shows Niraparib Extends Progression-Free Survival in Platinum-Sensitive Ovarian Cancer

Maintenance therapy with niraparib, an investigational oral PARP inhibitor, significantly prolonged progression-free survival (PFS) in patients with recurrent platinum-sensitive ovarian cancer regardless of BRCA status and homologous recombination deficiency (HRD) status. “This is a breakthrough for patients with ovarian cancer. We have never seen such large benefits in progression-free survival [ Read More ]

Encouraging Outcome with Adjuvant Sunitinib in Renal Cell Carcinoma

For the first time, a randomized study showed that adjuvant therapy improved outcomes in renal cell carcinoma (RCC). Adjuvant sunitinib improved disease-free survival (DFS) by more than 1 year in high-risk locoregional RCC following nephrectomy. Although this is encouraging news, some experts are not ready to adopt this as a [ Read More ]

Potentially Practice-Changing: Ribociclib/Letrozole Combo in Advanced Breast Cancer

The addition of the selective CDK4/6 inhibitor ribociclib to letrozole significantly improved progression-free survival (PFS) in hormone receptor–positive (HR+) advanced breast cancer. Compared with letrozole alone, the combination of ribociclib/letrozole improved PFS by 44%. These results from the phase 3 MONALEESA-2 trial were presented at the European Society for Medical [ Read More ]

Quality of Life Improved with Nivolumab versus Chemotherapy

In recent years, the cancer patient’s experience has been recognized as an important factor in determining the value of a treatment. According to patient reports, their quality of life (QOL) remained stable on the immunotherapy nivolumab, whereas it significantly deteriorated on chemotherapy, as shown in an analysis of a phase [ Read More ]

Published Studies Underreport Toxicities Associated with Targeted Therapy and Immunotherapy

Most oncologists’ knowledge about toxicities associated with newer therapies comes mainly from clinical trials, but publications of clinical trial safety results may be misleading, according to a study presented at the European Society for Medical Oncology 2016 Congress. The study investigators found suboptimal reporting of adverse events in studies of [ Read More ]

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